Fine-mapping of HLA associations with chronic lymphocytic ...Oct 23, 2014 ... risk of developing the disease,12,13 implicating genetic predisposition .....
detected at the antigen level because of opposing effects of alleles .... individual
allelic associations. Minority populations harbor specific HLA alleles that alter.
CLL risk. We also found that DRB1*09:01 (OR 5 2.00, P 5 2.31 3 1024. ).Regulatory Polymorphisms in Human DBH Affect Peripheral Gene ...Oct 17, 2014 ... sympathetic tone and disease risk. Methods and Results: Analysis of DBH mRNA
in human tissues confirmed high expression in the locus coeruleus (LC) and
adrenal gland, but also in sympathetically innervated organs (liver>lung>heart).
Allele- specific mRNA assays revealed pronounced allelic ...Hypersensitivity pneumonitis: a multifaceted deceiving disorderd'Examen de Santé de l'Assurance Maladie, Marseille. Results: Our results
confirm an increase of DRB1*15, HLA DRB1*11 and. DRB1*08 alleles in patients
with diffuse disease compared to controls. Among patients with limited disease,
only DRB1*08 is increased. Conclusion: HLA-DRB1*11 and some DRB1*08
alleles, ...Novel association between immune-mediated susceptibility loci and ...Sep 17, 2013 ... environmental risk factor for arthritis. autoimmunity; synovitis; erosion;
environment; innate. RHEUMATOID ARTHRITIS (RA) affects 0.5?1% of the
population. New insights about the inflammatory process in the joint and disease
pathogenesis have led to the development of new treatments during the past ...B cells and autoantibodies - Annals of the Rheumatic Diseasessupported by the gene dosage effect for DRB1*11 allele and the interaction of.
DRB1*11,*13, and *08. Lastly, no significant associations were detected between
spe- cific DRB1 alleles and relevant clinical features represented by the
presence of cirrhosis or serum autoantibodies. In conclusion, we confirm the role
for HLA ...
